Telcagepant CAS Number: 781649-09-0: Molecular Weight: 566.523: Density: 1.5±0.1 g/cm3: Boiling Point: N/A: Molecular Formula: C 26 H 27 F 5 N 6 O 3: Melting Point: N/A: MSDS: N/A Flash Point: N/A

The Vertex CGRP program was focused on identifying potent, orally bioavailable CGRP receptor antagonists that, in contrast to olcegepant and telcagepant, would be CNS-penetrant. 159 Starting from truncated analogs of olcegepant, they identified 165 (Fig. 36, K i = 280 nM) and optimized this flexible lead structure by incorporating conformational constraints.

Nov 1, 2019 peptide (CGRP) receptor antagonist telcagepant in human cranial arteries. in autonomic cardiovascular regulation and vascular structure. Telcagepant är en CGRP-receptorantagonist som kan tas peroralt och Telcagepant är ett substrat för PGP (ett enzym- meter Structure Consortium (nmC) vid. André Erdling · Centre for Mathematical Sciences. Library of Mathematics · Department of Architecture and Built Environment · Department of Automatic Control.

Structure General Activity Publications Application Names 8: Classification 1: Identifiers 7: Related Substances 3: TELCAGEPANT POTASSIUM L303VER2NG Investigational Source: NCT00442936: Phase 3 Interventional Completed Migraine (2007) Source URL: https MK-0974 (Telcagepant) is a potent and selective antagonist of the human and rhesus CGRP receptors. headgroup onto that observed in the PDB structure of telcagepant bound to the ectodomain of the CGRP receptor (PDB code 3N7R36) and generating 30 docks per compound using default options. Results were processed using an in-house script to cluster the docks and assess the quality of hydrogen bonds, identifying docks with high GOLD scores, no Structure Moieties 1: General Activity Publications Application Record Details Names 10: Classification 1: Identifiers 9 Relationships 1: Active Moiety 1: TELCAGEPANT D42O649ALL Investigational Source: NCT00442936: Phase 3 Migraine (2007 TELCAGEPANT D42O649ALL Overview Structure Names 10: Classification 1: Identifiers 11: Relationships 1: Active Moiety 1: Audit Info References 21: Moieties 1: Substance Class: Chemical Record UNII: D42O649ALL. Record Status: Validated: Record Version: Show Definitional References TELCAGEPANT POTASSIUM L303VER2NG Overview Structure Names 8: Classification 1: Identifiers 9: Relationships 2: Active Moiety 1: Notes 2: Audit Info References 19: Moieties 3: Substance Class: Chemical Record UNII: L303VER2NG.

Telcagepant. Molecular Formula C 26 H 27 F 5 N 6 O 3; Average mass 566.523 Da; Monoisotopic mass 566.206482 Da; ChemSpider ID 9494017

CGRP and its receptors are found in areas of the central and peripheral nervous system that are important for the transmission of migraine pain. 781649-09-0 - CGDZXLJGHVKVIE-DNVCBOLYSA-N - Telcagepant [USAN:INN] - Similar structures search, synonyms, formulas, resource links, and other chemical information.

MK-0974(Telcagepant) is a highly potent, selective, and orally bioavailable CGRP receptor antagonist with Ki values of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors respectively; displays >1500-fold lower affinity for the canine and rat receptors.;IC50 value: 0.77/1.2 nM(Human and rhesus CGRP) [1];Target: CGRP receptor;In vitro: MK-0974 is a potent antagonist of the human (K(i) = 0.77 nM) and rhesus (K(i) = 1.2 nM) CGRP receptors but displays >1500-fold lower affinity for the canine

781649-09-0 - CGDZXLJGHVKVIE-DNVCBOLYSA-N - Telcagepant [USAN:INN] - Similar structures search, synonyms, formulas, resource links, and other chemical information. Structure, properties, spectra, suppliers and links for: Telcagepant potassium, 953077-35-5.

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Structuralism is a school of thought in linguistics, psychology and anthropology.
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MK-0974 (Telcagepant) Chemical Structure CAS NO. 781649-09-0 MK-0974 (Telcagepant) is a potent and selective antagonist of the human and rhesus CGRP receptors.

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Structure General Activity Publications Application Names 8: Classification 1: Identifiers 7: Related Substances 3: TELCAGEPANT POTASSIUM L303VER2NG Investigational Source: NCT00442936: Phase 3 Interventional Completed Migraine (2007) Source URL: https

The antagonists olcegepant (BIBN4096BS) and telcagepant (MK-0974) are effective drugs in clinical trials for treatment of acute migraine ( Figure 2) [58], and molecular details about their binding and receptor selectivity will guide the development of future molecules.Olcegepant and telcagepant were developed by a classical medicinal chemistry approach following elegant structure-activity 2011-07-20 Media in category "Telcagepant" The following 2 files are in this category, out of 2 total.